Open Access
Article
RAGE and cardiovascular disease
Sungha Park1,Se-Jung Yoon1,Hyun-Jin Tae1,Chi Young Shim1
1
Division of Cardiology, Yonsei University College of Medicine, Seoul, South Korea. shpark0530@yuhs.ac
DOI: 10.2741/3700 Volume 16 Issue 2, pp.486-497
Published: 01 January 2011
(This article belongs to the Special Issue RAGE signaling)
Abstract

RAGE is pattern recognizing receptors for diverse endogenous ligands. RAGE activation by RAGE ligands is known to be associated with reactive oxygen species generation, activation of NF kappa B, as well as recruitment of proinflammatory cells. Activated endothelial cells, vascular smooth muscle cells in atherosclerotic plaques and activated inflammatory cells all have increased expression of RAGE, which with its interaction with RAGE ligands increases the secretion of proinflammatory cytokines and cell adhesion molecules. Furthermore, RAGE may have a significant role in leukocyte recruitment into the intima of the atherosclerosis. Initial insults resulting in endothelial dysfunction will result in leukocyte infiltration, oxidative stress and vascular inflammation that is amplified by RAGE activation. RAGE and its interaction with RAGE ligands may be important for initializing and maintaining the pathological processes that result in various entities of cardiovascular disease. Soluble RAGE competitively inhibits the binding of RAGE ligands to RAGE and attenuates the development of atherosclerosis in vivo. Thus RAGE may be a promising target for treatment of cardiovascular disease in the future.

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Sungha Park, Se-Jung Yoon, Hyun-Jin Tae, Chi Young Shim. RAGE and cardiovascular disease. Frontiers in Bioscience-Landmark. 2011. 16(2); 486-497.