Open Access
Article
Crystalline calcium carbonate and hydrogels as microenvironment for stem cells
Liliana Astachov1,Zvi Nevo1,Moran Aviv1,Razi Vago1
1
Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
DOI: 10.2741/3698 Volume 16 Issue 2, pp.458-471
Published: 01 January 2011
(This article belongs to the Special Issue Insights into musculo-skeletal stem cells biology)
Abstract

Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell--based on embryonic and adult stem cells as potent, cellular sources--for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.

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Liliana Astachov, Zvi Nevo, Moran Aviv, Razi Vago. Crystalline calcium carbonate and hydrogels as microenvironment for stem cells. Frontiers in Bioscience-Landmark. 2011. 16(2); 458-471.