Open Access
Receptor-mediated T cell absorption of antigen presenting cell-derived molecules
Inkyu Hwang1,DaLim Ki1
Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
DOI: 10.2741/3695 Volume 16 Issue 2, pp.411-421
Published: 01 January 2011
(This article belongs to the Special Issue Ligand uptake by immune cells; mechanism and significance)

T cells tend to acquire a variety of cell surface molecules derived from antigen presenting cells (APCs). The molecule uptake occurs mainly during direct T/APC contact and is instigated by specific receptor/ligand interactions, such as T cell receptor (TCR) with a cognate peptide/MHC complex (pMHC) or CD28 with B7. The acquired molecules are targeted for internalization and degradation in the lysosome. Nevertheless, those molecules are expressed on the surface of T cells for a period of time. The presentation of APC-derived ligands by T cells exhibited a multitude of immunological effects via antigen-specific T/T interaction upon recognition of the absorbed antigens by contact with other T cells. Ligand uptake also occurs via absorption of membrane vesicles shed from APCs prior to contact (e.g., exosomes and plasma membrane-derived vesicles). As in ligand absorption via direct T/APC interaction, the absorption of pre-formed membrane vesicles is also dependent on specific receptor/ligand interactions. In this review, biological mechanisms underlying the ligand absorption process as well as the biological significance and application of the event will be discussed.

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Inkyu Hwang, DaLim Ki. Receptor-mediated T cell absorption of antigen presenting cell-derived molecules. Frontiers in Bioscience-Landmark. 2011. 16(2); 411-421.