Open Access
Article
Molecular imaging metrics to evaluate response to preclinical therapeutic regimens
R Adam Smith1,Saffet Guleryuz1,H Charles Manning1
1
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical enter, Nashville, TN 37232, USA
DOI: 10.2741/3694 Volume 16 Issue 2, pp.393-410
Published: 01 January 2011
(This article belongs to the Special Issue Biomarkers of tumor response to tyrosine kinase inhibitors)
Abstract

Molecular imaging comprises a range of techniques, spanning not only several imaging modalities but also many disease states and organ sites. While advances in new technology platforms have enabled a deeper understanding of the cellular and molecular basis of malignancy, reliable non-invasive imaging metrics remain an important tool for both diagnostics and patient management. Furthermore, the non- invasive nature of molecular imaging can overcome shortcomings associated with traditional biological approaches and provide valuable information relevant to patient care. Integration of information from multiple imaging techniques has the potential to provide a more comprehensive understanding of specific tumor characteristics, tumor status, and treatment response.

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R Adam Smith, Saffet Guleryuz, H Charles Manning. Molecular imaging metrics to evaluate response to preclinical therapeutic regimens. Frontiers in Bioscience-Landmark. 2011. 16(2); 393-410.