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Amino acids and diabetes: implications for endocrine, metabolic and immune function
Philip Newsholme1,Fernando Abdulkader1,Eduardo Rebelato1,Talita Romanatto1,Carlos Hermano J Pinheiro1,Kaio Fernando Vitzel1,Erica Portioli Silva1,Roberto B Bazotte1,Joaquim Procopio1,Rui Curi1,Renata Gorjao1,Tania Cristina Pithon-Curi1
1
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute and UCD Institute for Sport and Health, UCD Dublin, Belield, Dublin 4, Ireland. philip.newsholme@ucd.ie
DOI: 10.2741/3690 Volume 16 Issue 1, pp.315-339
Published: 01 January 2011
(This article belongs to the Special Issue Amino acids in nutrition, health, and disease)
Abstract

Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.

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Philip Newsholme, Fernando Abdulkader, Eduardo Rebelato, Talita Romanatto, Carlos Hermano J Pinheiro, Kaio Fernando Vitzel, Erica Portioli Silva, Roberto B Bazotte, Joaquim Procopio, Rui Curi, Renata Gorjao, Tania Cristina Pithon-Curi. Amino acids and diabetes: implications for endocrine, metabolic and immune function. Frontiers in Bioscience-Landmark. 2011. 16(1); 315-339.