Open Access
TGF-beta-dependent and -independent roles of STRAP in cancer
Jennifer Elisabeth Reiner1,Pran K Datta1
Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
DOI: 10.2741/3678 Volume 16 Issue 1, pp.105-115
Published: 01 January 2011
(This article belongs to the Special Issue TGF-beta signaling and cancer)

The serine-threonine kinase receptor-associated protein (STRAP) was initially identified as a putative inhibitor of the canonical TGF-beta signaling pathway. Because the Smad-dependent TGF-beta pathway negatively regulates cellular growth, early functional studies suggested that STRAP behaves as an oncogene. Indeed, a correlation between STRAP overexpression and various cancers has been identified. With the emergence of new studies on the biological function of STRAP, it is becoming clear that STRAP regulates several distinct cellular processes and modulates multiple signaling pathways. While STRAP itself does not possess enzymatic activity, it appears that STRAP influences biological processes through associations with cellular proteins. In this review, we will describe the TGF-beta-dependent and -independent functions of STRAP and provide a context for the significance of STRAP activity in the development of cancer.

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Jennifer Elisabeth Reiner, Pran K Datta. TGF-beta-dependent and -independent roles of STRAP in cancer. Frontiers in Bioscience-Landmark. 2011. 16(1); 105-115.