Open Access
Is insulin resistance a disorder of the brain?
Undurti N Das1,Gaston Repossi1,Alejandro Dain1,Aldo Renato Eynard1
Jawaharlal Nehru Technological University, Kakinada 533 003, India.
DOI: 10.2741/3671 Volume 16 Issue 1, pp.1-12
Published: 01 January 2011
(This article belongs to the Special Issue Advances in metabolic syndrome and diabetes mellitus)

There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.

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Undurti N Das, Gaston Repossi, Alejandro Dain, Aldo Renato Eynard. Is insulin resistance a disorder of the brain?. Frontiers in Bioscience-Landmark. 2011. 16(1); 1-12.