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Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor
Vusi Mbazima1,Bianca Da Costa Dias1,Aadilah Omar1,Katarina Jovanovic1,Stefan F T Weiss1
1
School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa (RSA)
DOI: 10.2741/3667 Volume 15 Issue 3, pp.1150-1163
Published: 01 June 2010
(This article belongs to the Special Issue Cellular prion protein partners and signaling)
Abstract

The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue viruses, Alphaviruses and Adeno-associated viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions. Furthermore, the 37-kDa/67-kDa LRP/LR plays fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes. This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.

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Vusi Mbazima, Bianca Da Costa Dias, Aadilah Omar, Katarina Jovanovic, Stefan F T Weiss. Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor. Frontiers in Bioscience-Landmark. 2010. 15(3); 1150-1163.