Open Access
TRPC channels in smooth muscle cells
Jose C Gonzalez-Cobos1,Mohamed Trebak1
The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
DOI: 10.2741/3660 Volume 15 Issue 3, pp.1023-1039
Published: 01 June 2010

Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

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Jose C Gonzalez-Cobos, Mohamed Trebak. TRPC channels in smooth muscle cells. Frontiers in Bioscience-Landmark. 2010. 15(3); 1023-1039.