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Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity
Jietang Mai1,Hong Wang1,Xiao-Feng Yang1
1
Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
DOI: 10.2741/3657 Volume 15 Issue 3, pp.986-1006
Published: 01 June 2010
(This article belongs to the Special Issue Homeostasis and therapeutical potential of CD4)
Abstract

T helper 17 cells (Th17) are a new CD4+ T helper subset that has been implicated in inflammatory and autoimmune diseases. Th17, along with CD4(+)CD25(high) Foxp3(+) regulatory T cells (Tregs) and other new T helper subsets, have expanded the Th1-Th2 paradigm. Although this new eight-subset paradigm significantly improved our understanding on the differentiation and regulation of CD4+ T helper subsets, many questions remain to be answered. Here we will briefly review the following issues: a) Old Th1-Th2 paradigm versus new multi-subset paradigm; b) Structural features of IL-17 family cytokines; c) Th17 cells; d) Effects of IL-17 on various cell types and tissues; e) IL-17 receptor and signaling pathways; f) Th17-mediated inflammations; and g) Protective mechanisms of IL-17 in infections. Lastly, we will examine the interactions of Th17 and Treg in autoimmune diseases and inflammation: Th17 cells interplay with Tregs. Regulation of autoimmunity and inflammation lies in the interplays of the different T helper subsets, therefore, better understanding of these subsets' interactions would greatly improve our approaches in developing therapy to combat inflammatory and autoimmune diseases.

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Jietang Mai, Hong Wang, Xiao-Feng Yang. Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity. Frontiers in Bioscience-Landmark. 2010. 15(3); 986-1006.