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Replication protein A: directing traffic at the intersection of replication and repair
Greg G Oakley1,Steve M Patrick1
1
College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
DOI: 10.2741/3652 Volume 15 Issue 3, pp.883-900
Published: 01 June 2010
(This article belongs to the Special Issue DNA damage checkpoints, DNA repair and aging)
Abstract

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

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Greg G Oakley, Steve M Patrick. Replication protein A: directing traffic at the intersection of replication and repair. Frontiers in Bioscience-Landmark. 2010. 15(3); 883-900.