Open Access
Stroma-mediated expression of estrogen and its role in cancer
Mohit Sachdeva1,Yin-Yuan Mo1
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine and Simmons Cooper Cancer Institute, Springfield, IL 62794, USA
DOI: 10.2741/3618 Volume 15 Issue 1, pp.237-248
Published: 01 January 2010
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)

Several hormones are well known for their role in tumorigenesis. Among them estrogen is the best characterized hormone. In particular, stromal tissue-produced estrogen plays a key role in breast tumor development and progression, highlighting the importance of communications between stromal tissue and tumor cells in the tumor microenvironment. In this review, we update our current understanding of stroma-mediated expression of hormones (estrogen) and their role in tumorigenesis, focusing on how aromatase produced in stromal tissue affects tumor cell growth. We also briefly touch on hormone therapy involving selective estrogen receptor modulators and aromatase inhibitors.

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Mohit Sachdeva, Yin-Yuan Mo. Stroma-mediated expression of estrogen and its role in cancer. Frontiers in Bioscience-Landmark. 2010. 15(1); 237-248.