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Cancer associated fibroblasts (CAFs) in tumor microenvironment
Fei Xing1,Jamila Saidou1,Kounosuke Watabe1
1
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, School of Medicine, 751 N Rutledge St. PO Box 19626, Springfield, IL 627794-9626, USA
DOI: 10.2741/3613 Volume 15 Issue 1, pp.166-179
Published: 01 January 2010
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.

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Fei Xing, Jamila Saidou, Kounosuke Watabe. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Frontiers in Bioscience-Landmark. 2010. 15(1); 166-179.