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Growth factors in tumor microenvironment
Xuejing Zhang1,Daotai Nie1,Subhas Chakrabarty1
1
SimmonCooper Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
DOI: 10.2741/3612 Volume 15 Issue 1, pp.151-165
Published: 01 January 2010
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also discusses how deregulation of these growth factors or their receptors can drive malignant transformation and progression.

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Xuejing Zhang, Daotai Nie, Subhas Chakrabarty. Growth factors in tumor microenvironment. Frontiers in Bioscience-Landmark. 2010. 15(1); 151-165.