Open Access
Article
Replication licensing and the DNA damage checkpoint
Jeanette Gowen Cook1
1
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center Campus Box 7260, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jean_cook@med.unc.edu
DOI: 10.2741/3584 Volume 14 Issue 13, pp.5013-5030
Published: 01 June 2009
(This article belongs to the Special Issue Cancer vaccine)
Abstract

Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings suggest that checkpoints and replication are more intimately associated than previously appreciated, even in the absence of exogenous DNA damage. This review summarizes some of these developments.

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Jeanette Gowen Cook. Replication licensing and the DNA damage checkpoint. Frontiers in Bioscience-Landmark. 2009. 14(13); 5013-5030.