Open Access
Bioengineered corneas for transplantation and in vitro toxicology
Christopher R McLaughlin1,Ray J-F Tsai1,Malcolm A Latorre1,May Griffith1
University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
DOI: 10.2741/3455 Volume 14 Issue 9, pp.3326-3337
Published: 01 January 2009

Bioengineered corneas have been designed to replace partial or the full-thickness of defective corneas, as an alternative to using donor tissues. They range from prosthetic devices that solely address replacement of the cornea's function, to tissue engineered hydrogels that permit regeneration of host tissues. In cases where corneal stem cells have been depleted by injury or disease, most frequently involving the superficial epithelium, tissue engineered lamellar implants reconstructed with stem cells have been transplanted. In situ methods using ultraviolet A (UVA) crosslinking have also been developed to strengthen weakened corneas. In addition to the clinical need, bioengineered corneas are also rapidly gaining importance in the area of in vitro toxicology, as alternatives to animal testing. More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested.

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Christopher R McLaughlin, Ray J-F Tsai, Malcolm A Latorre, May Griffith. Bioengineered corneas for transplantation and in vitro toxicology. Frontiers in Bioscience-Landmark. 2009. 14(9); 3326-3337.