Open Access
Mouse models to study angiogenesis in the context of cardiovascular diseases
Thierry Couffinhal1,Pascale Dufourcq1,Laurent Barandon1,Lionel Leroux1,Cecile Duplaa1
Institut National de la Sante et de la Recherche Medicale, Inserm U828, Pessac, France; Universite Victor Segalen Bordeaux 2, Bordeaux, France.
DOI: 10.2741/3454 Volume 14 Issue 9, pp.3310-3325
Published: 01 January 2009

Pathological angiogenesis is a hallmark of various ischemic diseases (insufficient vessel growth) but also of cancer and metastasis, inflammatory diseases, blindness, psoriasis or arthritis (excessive angiogenesis). In response to ischemia (reduced blood flow and oxygen supply), new blood vessels form in order to compensate for the lack of perfusion. This natural process could protect them from the consequences of atherosclerotic diseases (myocardial angina, infarction, hindlimb arteriopathy or stroke). However, neovessel formation is altered in many patients. A better understanding of the mechanisms of functional vessel formation is a pre-requisite to improving the treatment of ischemic pathologies. To this end, it is essential to create easily accessible animal models in which vessel formation can be both manipulated and studied. In this review, we will describe different angiogenic mouse models in the context of cardiovascular diseases, either in an ischemic context (hindlimb ischemia, heart ischemia, skin model) or in a non-ischemic context (plug and eye assay, wound healing, ovarian model). We will also discuss quantitative techniques for assessing angiogenesis in these assays.

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Thierry Couffinhal, Pascale Dufourcq, Laurent Barandon, Lionel Leroux, Cecile Duplaa. Mouse models to study angiogenesis in the context of cardiovascular diseases. Frontiers in Bioscience-Landmark. 2009. 14(9); 3310-3325.