Open Access
A network of miRNAs expressed in the ovary are regulated by FSH
Nan Yao1,Cai-Ling Lu1,Jian-Jun Zhao1,Hong-Fei Xia1,Da-Guang Sun1,Xin-Quan Shi1,Chong Wang1,Dan Li1,Yi Cui1,Xu Ma1
Graduate School of Peking Union Medical College, Beijing, China
DOI: 10.2741/3447 Volume 14 Issue 9, pp.3239-3245
Published: 01 January 2009

The process of folliculogenesis requires a tightly regulated series of gene expression that are a pre-requisite to the development of ovarian follicle. Among these genes, follicle-stimulating hormone (FSH) is notable for its dual role in development of follicles as well as proliferation and differentiation of granulosa cells. The post-transcriptional expression of these genes is under the control of microRNAs (miRNAs), a class of small, endogenous RNAs that negatively impact gene expression. This study was carried out to determine the role of several miRNAs including mir-143, let-7a, mir-125b, let-7b, let-7c, mir-21 in follicular development in the mouse. The expression of these RNAs was very low in primordial follicles but these became readily detectable in the granulosa cells of primary, secondary and antral follicles. We show that this expression of some miRNAs (mir-143, let-7a, mir-15b) is under negative control of FSH. Together, these findings suggest that FSH regulates folliculogenesis by a novel pathway of miRNAs.

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Nan Yao, Cai-Ling Lu, Jian-Jun Zhao, Hong-Fei Xia, Da-Guang Sun, Xin-Quan Shi, Chong Wang, Dan Li, Yi Cui, Xu Ma. A network of miRNAs expressed in the ovary are regulated by FSH. Frontiers in Bioscience-Landmark. 2009. 14(9); 3239-3245.