Open Access
Innate immunity, coagulation and surgery
Alexander Koch1,Paula Zacharowski1,Olaf Boehm1,Kai Zacharowski1
Molecular Cardioprotection and Inflammation Group, University Hospitals Bristol NHS Foundation Trust, Bristol, BS2 8HW, United Kingdom
DOI: 10.2741/3427 Volume 14 Issue 8, pp.2970-2982
Published: 01 January 2009
(This article belongs to the Special Issue Perioperative immunity and outcome)

Inflammation is the host's defense mechanism to infection or trauma including surgical procedures. In the clinic, non-infectious inflammation plays an important part in cardiology (e.g. Percutaneous transluminal coronary angioplasty, PTCA), intensive care medicine (e.g. polytrauma), cardiac (e.g. extracorporeal circulation) and vascular surgery (e.g. reperfusion injury). An imbalance of the inflammatory response can cause an acute condition like sepsis or long-term Cardiovascular disease (CVD), both of which are leading killers in the Western world. Alterations in coagulation, innate immunity and endothelial function represent key aspects in the mechanism of inflammation and are the link between the pathogenesis of these two diseases. Studying inflammatory pathways or targeting specific mediators during inflammation may help to develop strategies to improve the clinical outcome of patients undergoing major surgery, where postoperative inflammation plays a crucial role.

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Alexander Koch, Paula Zacharowski, Olaf Boehm, Kai Zacharowski. Innate immunity, coagulation and surgery. Frontiers in Bioscience-Landmark. 2009. 14(8); 2970-2982.