Open Access
Article
Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
Tong Zhou1,Xiao Li1,Jie Zou1,Minchao Cai1,Guizhi Sun1,Yumei Zhang1,Yapeng Zhao1,Mingjun Zhang1,Yanyun Zhang1,Nan Chen1
1
Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui jin Er road, Shanghai 200025, China. zhoutong_cn@hotmail.com
DOI: 10.2741/3424 Volume 14 Issue 8, pp.2935-2943
Published: 01 January 2009
(This article belongs to the Special Issue Immune pathology)
Abstract

Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is important for dendritic cell (DC) in migrating, recognizing, capturing, presenting antigens and in initiating T cell responses. In the present study, we investigated the role of DC-SIGN in renal tubulointerstitial inflammation and fibrosis. DC-SIGN was mainly expressed in tubular epithelial cells and DC-SIGN+ DCs were primarily distributed in renal tubulointerstitial areas during the early stage of nephritis, which was correlated with the degree of renal tubular interstitial lesions and fibrosis. In vitro, DC-SIGN expression in cultured human renal tubular epithelial cells was elevated when treated by tumor necrosis factor-alpha, and was inhibited by anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb). In a rat model of chronic renal interstitial fibrosis, there was a significant correlation of DC-SIGN expression with DC-SIGN+ DC distribution and the degree of tubulointerstitial lesion. PsL-EGFmAb reduced DC-SIGN expression and DC-SIGN+ DC accumulation in renal tissues in this rat model. These results suggest that DC-SIGN plays an important role in DC-mediated renal tubular interstitial lesions induced by immuno-inflammatory responses.

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Tong Zhou, Xiao Li, Jie Zou, Minchao Cai, Guizhi Sun, Yumei Zhang, Yapeng Zhao, Mingjun Zhang, Yanyun Zhang, Nan Chen. Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis. Frontiers in Bioscience-Landmark. 2009. 14(8); 2935-2943.