Open Access
Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
Tong Zhou1,Xiao Li1,Jie Zou1,Minchao Cai1,Guizhi Sun1,Yumei Zhang1,Yapeng Zhao1,Mingjun Zhang1,Yanyun Zhang1,Nan Chen1
Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui jin Er road, Shanghai 200025, China.
DOI: 10.2741/3424 Volume 14 Issue 8, pp.2935-2943
Published: 01 January 2009
(This article belongs to the Special Issue Immune pathology)

Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is important for dendritic cell (DC) in migrating, recognizing, capturing, presenting antigens and in initiating T cell responses. In the present study, we investigated the role of DC-SIGN in renal tubulointerstitial inflammation and fibrosis. DC-SIGN was mainly expressed in tubular epithelial cells and DC-SIGN+ DCs were primarily distributed in renal tubulointerstitial areas during the early stage of nephritis, which was correlated with the degree of renal tubular interstitial lesions and fibrosis. In vitro, DC-SIGN expression in cultured human renal tubular epithelial cells was elevated when treated by tumor necrosis factor-alpha, and was inhibited by anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb). In a rat model of chronic renal interstitial fibrosis, there was a significant correlation of DC-SIGN expression with DC-SIGN+ DC distribution and the degree of tubulointerstitial lesion. PsL-EGFmAb reduced DC-SIGN expression and DC-SIGN+ DC accumulation in renal tissues in this rat model. These results suggest that DC-SIGN plays an important role in DC-mediated renal tubular interstitial lesions induced by immuno-inflammatory responses.

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Tong Zhou, Xiao Li, Jie Zou, Minchao Cai, Guizhi Sun, Yumei Zhang, Yapeng Zhao, Mingjun Zhang, Yanyun Zhang, Nan Chen. Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis. Frontiers in Bioscience-Landmark. 2009. 14(8); 2935-2943.