Open Access
TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium
Yong Sook Kim1,Hye Jung Park1,Moon Hwa Hong1,Peter M Kang1,James P Morgan1,Myung Ho Jeong1,Jeong Gwan Cho1,Jong Chun Park1,Youngkeun Ahn1
Cardiovascular Research Institute, Chonnam National University, Gwanju, South Korea
DOI: 10.2741/3417 Volume 14 Issue 8, pp.2845-2856
Published: 01 January 2009
(This article belongs to the Special Issue Genetic and cellular therapies in cardiovascular diseases)

TNF-alpha released from ischemic heart after acute MI increases the production of other cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). Activation of nuclear factor kappa B (NF-kappa B) by TNF-alpha , up-regulates the expression of molecules which are involved in inflammation and cell adhesion. For these reasons, we assessed the extent that treatment of MSC with tumor necrosis factor (TNF)-alpha modifies the characteristics of MSC, important to their engraftment in experimental myocardial infarct. Here, we show that pre-treatment of MSC prior to transplantation with tumor necrosis factor (TNF)-alpha increases adhesiveness, and migration of MSC in vitro and leads to increased expression of bone morphogenetic protein (BMP)-2 by MSC. Moreover, this treatment increases the rate of engraftment of MSC and improves recovery of cardiac function after myocardial infarction. These insights might provide better strategies for the treatment of myocardial infarction.

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Yong Sook Kim, Hye Jung Park, Moon Hwa Hong, Peter M Kang, James P Morgan, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Youngkeun Ahn. TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium. Frontiers in Bioscience-Landmark. 2009. 14(8); 2845-2856.