Open Access
Mechanism of cytokine modulation of epithelial tight junction barrier
Rana Al-Sadi1,Michel Boivin1,Thomas Ma1
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
DOI: 10.2741/3413 Volume 14 Issue 7, pp.2765-2778
Published: 01 January 2009
(This article belongs to the Special Issue Molecular engines that build and break epithelial junctions)

Cytokines play a crucial role in the modulation of inflammatory response in the gastrointestinal tract. Pro-inflammatory cytokines including tumor necrosis factor-alpha, interferon-gamma, interleukin-1beta?IL-1beta?, and interleukin-12 are essential in mediating the inflammatory response, while anti-inflammatory cytokines including interleukin-10 and transforming growth factor-beta are important in the attenuation or containment of inflammatory process. It is increasingly recognized that cytokines have an important physiological and pathological effect on intestinal tight junction (TJ) barrier. Consistent with their known pro-inflammatory activities, pro-inflammatory cytokines cause a disturbance in intestinal TJ barrier, allowing increased tissue penetration of luminal antigens. Recent studies indicate that the inhibition of cytokine induced increase in intestinal TJ permeability has an important protective effect against intestinal mucosal damage and development of intestinal inflammation. In this review, the effects of various pro-inflammatory and anti-inflammatory cytokines on intestinal TJ barrier and the progress into the mechanisms that mediate the cytokine modulation of intestinal TJ barrier are reviewed.

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Rana Al-Sadi, Michel Boivin, Thomas Ma. Mechanism of cytokine modulation of epithelial tight junction barrier. Frontiers in Bioscience-Landmark. 2009. 14(7); 2765-2778.