Open Access
Article
Horizontal DNA and mRNA transfer between donor and recipient cells after allogeneic hematopoietic cell transplantation?
Miguel Waterhouse1,Maria Themeli1,Yannis Metaxas1,Eleni D Lagadinou1,Jurgen Finke1,Alexandros Spyridonidis1
1
Department of Hematology and Oncology, Albert-Ludwigs University Medical Center, Freiburg, Germany
DOI: 10.2741/3407 Volume 14 Issue 7, pp.2704-2713
Published: 01 January 2009
Abstract

Allogeneic hematopoietic cell transplantation in humans results in true biological chimeras. There is now accumulating evidence that besides Graft versus Host Disease (GvHD), there are also other consequences in the co-existence of two genetically distinct populations in the transplant recipient. First, epithelial cells with donor-derived genotype emerge. Second, epithelial tissues of the host acquire genomic alterations. The current review discusses existing data on these recently discovered phenomena and focuses on horizontal gene transfer between donor and recipient cells as a possible mechanism explaining and linking these phenomena.

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Miguel Waterhouse, Maria Themeli, Yannis Metaxas, Eleni D Lagadinou, Jurgen Finke, Alexandros Spyridonidis. Horizontal DNA and mRNA transfer between donor and recipient cells after allogeneic hematopoietic cell transplantation?. Frontiers in Bioscience-Landmark. 2009. 14(7); 2704-2713.