Open Access
Role of phosphoinositide 3-kinases in regulating cardiac function
Lynette Pretorius1,Kate L Owen1,Julie R McMullen1
Baker IDI Heart and Diabetes Institute, Melbourne Victoria, 8008, Australia
DOI: 10.2741/3374 Volume 14 Issue 6, pp.2221-2229
Published: 01 January 2009
(This article belongs to the Special Issue Calcium and the heart: signaling and regulation)

Phosphoinositide 3-kinases (PI3Ks) are important signaling proteins in the heart. Class IA PI3Ks (p110alpha, beta) are critical regulators of physiological heart growth and cell survival, and are generally considered to be beneficial for heart function. In contrast, activation of class IB PI3K(p110gamma) is detrimental for heart function, reducing cardiac contractility. This may have implications for the treatment of heart disease and failure. In vitro, ex vivo and in vivo studies have contributed to our understanding of PI3K signaling in the heart. This review summarizes class I PI3K signaling in the regulation of cardiac function, with a particular focus on the role of different PI3K isoforms in settings of heart disease.

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Lynette Pretorius, Kate L Owen, Julie R McMullen. Role of phosphoinositide 3-kinases in regulating cardiac function. Frontiers in Bioscience-Landmark. 2009. 14(6); 2221-2229.