Open Access
Neuropeptides in tendinopathy
Alexander Scott1,Roald Bahr1
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
DOI: 10.2741/3372 Volume 14 Issue 6, pp.2203-2211
Published: 01 January 2009
(This article belongs to the Special Issue Tendons: the next frontier)

Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted the role of sensory and autonomic nerves in generating or perpetuating the symptoms and tissue abnormalities associated with tendinopathy. We outline the neuroanatomy and potential roles of nerves and associated neuropeptides in tendinopathy. In addition, intriguing new data is reviewed which suggests that there may be a substantial intrinsic source of neuropeptides within tendons - namely, the tenocytes themselves. The potential roles of Substance P and mast cells are highlighted in particular. We discuss the implications for conservative management including sclerosing injections and exercise training.

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Alexander Scott, Roald Bahr. Neuropeptides in tendinopathy. Frontiers in Bioscience-Landmark. 2009. 14(6); 2203-2211.