Open Access
Apoptotic signaling cascades operating in poliovirus-infected cells
Bruno Blondel1,Arnaud Autret1,Cynthia Brisac1,Sandra Martin-Latil1,Laurence Mousson1,Isabelle Pelletier1,Jerome Estaquier1,Florence Colbere-Garapin1
Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France.
DOI: 10.2741/3370 Volume 14 Issue 6, pp.2181-2192
Published: 01 January 2009
(This article belongs to the Special Issue Apoptosis and mitochondria)

The flaccid paralyses characteristic of poliomyelitis are a direct consequence of the infection of motor neurons with poliovirus (PV). In PV-infected mice, motor neurons die by apoptosis. However, the mechanisms by which PV induces cell death in neurons remain unclear. Analyses of the apoptotic pathways induced by PV infection in several cell lines have demonstrated that mitochondria play a key role in PV-induced apoptosis. Furthermore, mitochondrial dysfunction results from an imbalance between pro- and anti-apoptotic pathways. We present here an overview of the many studies of PV-induced apoptosis carried out in recent years and discuss the contribution of these studies to our understanding of poliomyelitis.

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Bruno Blondel, Arnaud Autret, Cynthia Brisac, Sandra Martin-Latil, Laurence Mousson, Isabelle Pelletier, Jerome Estaquier, Florence Colbere-Garapin. Apoptotic signaling cascades operating in poliovirus-infected cells. Frontiers in Bioscience-Landmark. 2009. 14(6); 2181-2192.