Open Access
Ovarian cancer: pathology, biology, and disease models
Daniel G Rosen1,Gong Yang1,Guangzhi Liu1,Imelda Mercado-Uribe1,Bin Chang1,Xue Sherry Xiao1,Jingfang Zheng1,Feng-Xia Xue1,Jinsong Liu1
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77005-4095, USA
DOI: 10.2741/3364 Volume 14 Issue 6, pp.2089-2102
Published: 01 January 2009
(This article belongs to the Special Issue Cyclic nucleotide signaling and drug discovery)

Epithelial ovarian cancer, which comprises several histologic types and grades, is the most lethal cancer among women in the United States. In this review, we summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease.

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Daniel G Rosen, Gong Yang, Guangzhi Liu, Imelda Mercado-Uribe, Bin Chang, Xue Sherry Xiao, Jingfang Zheng, Feng-Xia Xue, Jinsong Liu. Ovarian cancer: pathology, biology, and disease models. Frontiers in Bioscience-Landmark. 2009. 14(6); 2089-2102.