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Article
Differential calcium signalling in neuronal-glial networks
Alexei Verkhratsky1,Miroslava Anderova1,Alexandr Chvatal1
1
Institute of Experimental Medicine, ASCR, Videnska 1083, 142 20 Prague 4, Czech Republic. alex.verkhratsky@manchester.ac.uk
DOI: 10.2741/3359 Volume 14 Issue 6, pp.2004-2016
Published: 01 January 2009
Abstract

Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.

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Alexei Verkhratsky, Miroslava Anderova, Alexandr Chvatal. Differential calcium signalling in neuronal-glial networks. Frontiers in Bioscience-Landmark. 2009. 14(6); 2004-2016.