Open Access
Article
Cytokine Regulation of AMPK signalling
Gregory R Steinberg1,Matthew J Watt1,Mark A Febbraio1
1
St. Vincent's Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. gsteinberg@svi.edu.au
DOI: 10.2741/3350 Volume 14 Issue 5, pp.1902-1916
Published: 01 January 2009
(This article belongs to the Special Issue AMP-activated protein kinase)
Abstract

The dynamic control of energy metabolism is dependent on balancing energy demand with energy supply. In mammals this balance is maintained through the integration of many different cytokine signals that communicate the nutrient status of the organism to the hypothalamus, liver and skeletal muscle. Adipose tissue and resident macrophages secrete many of these cytokine factors including leptin, tumour necrosis factor a, adiponectin, interleukin-6 and resistin. Other secreted factors including ciliary neurotrophic factor and ghrelin have also been shown to regulate energy metabolism. The AMP-activated protein kinase (AMPK) has emerged as an important integrator of these cytokine signals regulating both central and peripheral pathways controlling food intake, energy expenditure and substrate utilization and as such is the focus of this review.

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Gregory R Steinberg, Matthew J Watt, Mark A Febbraio. Cytokine Regulation of AMPK signalling. Frontiers in Bioscience-Landmark. 2009. 14(5); 1902-1916.