Open Access
Deep brain stimulation for refractory obsessive-compulsive disorder
Adam Burdick1,Wayne K Goodman1,Kelly D Foote1
University of Florida, Department of Neurosurgery, PO Box 100265, Gainesville, FL, 32610, USA
DOI: 10.2741/3348 Volume 14 Issue 5, pp.1880-1890
Published: 01 January 2009

The use of deep brain stimulation (DBS) for obsessive compulsive disorder (OCD) is reviewed, including a brief discussion of historical groundwork in the surgical treatment of psychiatric disorders, and the rationale for the current practice. The theoretical neuroanatomic circuitry underlying the pathophysiology of OCD is presented, along with supporting neuroimaging and clinical evidence. The promising early results of DBS for OCD are summarized, including a discussion of current targets and programming issues. Finally, the ethical implications of the procedure are briefly discussed.

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Adam Burdick, Wayne K Goodman, Kelly D Foote. Deep brain stimulation for refractory obsessive-compulsive disorder. Frontiers in Bioscience-Landmark. 2009. 14(5); 1880-1890.