Open Access
Article
Cognition in multiple sclerosis: a review of neuropsychological and fMRI research
Helen M Genova1,James F Sumowski1,Nancy Chiaravalloti1,Gerald T Voelbel1,John Deluca1
1
Kessler Foundation Research Center, 300 Executive Drive, Suite 10, West Orange, NJ 07052, USA. hgenova@kmrrec.org
DOI: 10.2741/3336 Volume 14 Issue 5, pp.1730-1744
Published: 01 January 2009
(This article belongs to the Special Issue Multiple sclerosis: from molecules to therapeutics)
Abstract

Multiple Sclerosis (MS) is a disease of the central nervous system affecting millions of people worldwide. In addition to the disabling physical symptoms of MS, roughly 65% of individuals with MS also experience significant cognitive dysfunction, especially in the domains of learning/memory, processing speed (PS) and working memory (WM). The purpose of this review is to examine major topics in research on cognitive dysfunction, as well as review recent functional magnetic resonance imaging (fMRI) studies focusing on cognitive dysfunction in MS. Additionally, directions for future research are discussed.

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Helen M Genova, James F Sumowski, Nancy Chiaravalloti, Gerald T Voelbel, John Deluca. Cognition in multiple sclerosis: a review of neuropsychological and fMRI research. Frontiers in Bioscience-Landmark. 2009. 14(5); 1730-1744.