Open Access
RNA-protein interactions in hepadnavirus reverse transcription
Jianming Hu1,Li Lin1
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
DOI: 10.2741/3328 Volume 14 Issue 5, pp.1606-1618
Published: 01 January 2009
(This article belongs to the Special Issue Protein-RNA interactions in viral RNA processing)

The small DNA genome of hepadnaviruses is replicated by reverse transcription via an RNA intermediate. This RNA "pregenome" contains important signals that control critical steps of viral replication, including RNA packaging, initiation of reverse transcription, and elongation of minus strand DNA, through specific interactions with the viral reverse transcriptase, the capsid protein, and host factors. In particular, the interaction between the viral reverse transcriptase and RNA pregenome requires a host chaperone complex composed of the heat shock protein 90 and its cochaperones.

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Jianming Hu, Li Lin. RNA-protein interactions in hepadnavirus reverse transcription. Frontiers in Bioscience-Landmark. 2009. 14(5); 1606-1618.