Open Access
Article
Regulation of epithelial apical junctional complex by Rho family GTPases
Stanislav Samarin1,Asma Nusrat1
1
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 30322, USA
DOI: 10.2741/3298 Volume 14 Issue 3, pp.1129-1142
Published: 01 January 2009
(This article belongs to the Special Issue Molecular engines that build and break epithelial junctions)
Abstract

The apical junctional complex (AJC), encompassing the tight junction (TJ) and adherens junction (AJ) plays a vital role in regulating epithelial cell differentiation and barrier function of simple epithelia. Both AJ and TJ are comprised of multiprotein complexes consisting of transmembrane proteins, which interact with the underlying cytoskeleton via cytoplasmic scaffold proteins. These interactions are tightly controlled by a number of signaling proteins that are critical for the regulation of the AJC function. Among these signaling molecules Rho family of small GTPases have been demonstrated to regulate the AJC function in diverse physiological and pathological states. In this review we will focus on experimental data addressing the role of Rho GTPase family members, Rho, Rac and Cdc42 in the regulation of epithelial AJC, and analyze Rho GTPase-mediated signaling pathways that control maintenance, disassembly and assembly of the AJC in epithelial cells.

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Stanislav Samarin, Asma Nusrat. Regulation of epithelial apical junctional complex by Rho family GTPases. Frontiers in Bioscience-Landmark. 2009. 14(3); 1129-1142.