Open Access
Bone cells-biomaterials interactions
Marie-Eve Marquis1,Etienne Lord1,Eric Bergeron1,Olivier Drevelle1,Hyunjin Park1,Francois Cabana1,Helena Senta1,Nathalie Faucheux1
Laboratory of Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1
DOI: 10.2741/3293 Volume 14 Issue 3, pp.1023-1067
Published: 01 January 2009

With the aging population, the incidence of bone defects due to fractures, tumors and infection will increase. Therefore, bone replacement will become an ever bigger and more costly problem. The current standard for bone replacement is autograft, because these transplants are osteoconductive and osteoinductive. However, harvesting an autograft requires additional surgery at the donor site that is related to high level of morbidity. In addition, the quantity of bone tissue that can be harvested is limited. These limitations have necessitated the pursuit of alternatives using biomaterials. The control of bone tissue cell adhesion to biomaterials is an important requirement for the successful incorporation of implants or the colonization of scaffolds for tissue repair. Controlling cells-biomaterials interactions appears of prime importance to influence subsequent biological processes such as cell proliferation and differentiation. Therefore, interactions of cells with biomaterials have been widely studied especially on two-dimensional systems. This review focuses on these interactions.

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Marie-Eve Marquis, Etienne Lord, Eric Bergeron, Olivier Drevelle, Hyunjin Park, Francois Cabana, Helena Senta, Nathalie Faucheux. Bone cells-biomaterials interactions. Frontiers in Bioscience-Landmark. 2009. 14(3); 1023-1067.