Open Access
Article
Peroxisome proliferator-activated receptors and renal diseases
Jing Wu1,Lihong Chen1,Dongjuan Zhang1,Ming Huo1,Xiaoyan Zhang1,Dan Pu1,Youfei Guan1
1
Department of Physiology and Pathophysiology, Peking (Beijing) University Diabetes Center, Key Laboratory of Molecular Cardiovascular Science, Peking (Beijing) University Health Science Center, Beijing, China
DOI: 10.2741/3291 Volume 14 Issue 3, pp.995-1009
Published: 01 January 2009
(This article belongs to the Special Issue New insights into the pathogenesis and therapeutics of renal fibrosis)
Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Three isoforms of PPAR, i.e., PPAR-a, -d, and -?, have been identified and are differentially expressed in various tissues, including the kidney. The target genes of PPARs are involved in diverse biological processes, including adipogenesis, lipid metabolism, insulin sensitivity, inflammatory response, reproduction, and cell growth and differentiation. PPARs have been reported to protect against renal injury through indirect systemic effects and/or direct renal effects in diabetic nephropathy, glomerulonephritis, renal cell carcinoma, acute renal failure and chronic renal disease. In this review, we summarize the role of the three identified PPAR isoforms, PPARa, -d, and -?, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases.

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Jing Wu, Lihong Chen, Dongjuan Zhang, Ming Huo, Xiaoyan Zhang, Dan Pu, Youfei Guan. Peroxisome proliferator-activated receptors and renal diseases. Frontiers in Bioscience-Landmark. 2009. 14(3); 995-1009.