Open Access
Article
The divergence and interplay between pDC and mDC in humans
Norimitsu Kadowaki1
1
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. kadowaki@kuhp.kyoto-u.ac.jp
DOI: 10.2741/3279 Volume 14 Issue 3, pp.808-817
Published: 01 January 2009
(This article belongs to the Special Issue Immunotherapy based on innate lymphocytes)
Abstract

Induction of appropriate types of innate and adaptive immune responses depending on the nature of antigens is crucial to cope with a variety of pathogens and concurrently to avoid pathological reaction to self antigens. Recent studies have been elucidating that the diversity of immune responses is critically controlled by dendritic cells (DCs). Two DC subsets have been identified in humans: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). The DC subsets recognize different microbial pathogens by expressing distinct repertoires of Toll-like receptors, and induce different types of innate and adaptive immune responses depending on environmental factors. Particularly, pDC precursors produce vast amounts of type I interferons in response to viruses and thus play an important role in anti-viral immunity. In addition, type I interferons derived from pDCs are instrumental in activating mDCs. Elucidating cellular and molecular mechanisms by which functions of the two DC subsets are modulated will lead to understanding the pathogenesis of various immune-related diseases and to developing novel immunological therapies.

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Norimitsu Kadowaki. The divergence and interplay between pDC and mDC in humans. Frontiers in Bioscience-Landmark. 2009. 14(3); 808-817.