Open Access
Enhancing oxygen solubility using hemoglobin- and perfluorocarbon-based carriers
Valerie Centis1,Patrick Vermette1
Laboratoire de Bioingenierie et de Biophysique de , Universite de Sherbrooke, Department of Chemical Engineering, Universite de Sherbrooke, 2500, boul. de l'Universite, Sherbrooke, Quebec, Canada, J1K 2R1
DOI: 10.2741/3272 Volume 14 Issue 2, pp.665-688
Published: 01 January 2009

The objective of this paper is to review the properties of fluids capable to enhance oxygen transport and transfer and recent developments in this field. This paper reviews and compares two different approaches, which could be used to solve the important problem of oxygen supply in some cell and tissue cultures: 1) hemoglobin-based and 2) perfluorocarbon-based (PFC) oxygen carriers. Several types of modified hemoglobin-based oxygen carriers (HBOCs) and their preparation are reviewed, as well as advances in the field of PFC oxygen carriers. Finally, we highlight the advantages and pitfalls, when reported in the literature, associated with each technique.

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Valerie Centis, Patrick Vermette. Enhancing oxygen solubility using hemoglobin- and perfluorocarbon-based carriers. Frontiers in Bioscience-Landmark. 2009. 14(2); 665-688.