Open Access
Article
The role of death receptors in neural injury
Corina Lorz1,Huseyin Mehmet1
1
Weston Laboratory, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, London, UK. clorz@ciemat.es
DOI: 10.2741/3265 Volume 14 Issue 2, pp.583-595
Published: 01 January 2009
(This article belongs to the Special Issue Mechanisms of neuronal Injury in neurological diseases)
Abstract

Programmed cell death is an essential process in the development of the central nervous system (CNS) and is fundamental for the control of the final number of neurons and glial cells. Excessive cell death has been implicated in a growing number of neurodegenerative diseases, such as Alzheimer's, Parkinson's, and multiple sclerosis as well as ischemic injury. We review the contribution of death receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family to cell death and survival in the context of CNS pathology, indicating the possible value of manipulating cell death induced by these receptors for the treatment of CNS diseases and injury.

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Corina Lorz, Huseyin Mehmet. The role of death receptors in neural injury. Frontiers in Bioscience-Landmark. 2009. 14(2); 583-595.