Open Access
Article
Chemokines and chemokine receptors: an overview
Raffaella Bonecchi1,Emanuela Galliera1,Elena Monica Borroni1,Massimiliano Marco Corsi1,Massimo Locati1,Alberto Mantovani1
1
Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Italy
DOI: 10.2741/3261 Volume 14 Issue 2, pp.540-551
Published: 01 January 2009
Abstract

Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

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Raffaella Bonecchi, Emanuela Galliera, Elena Monica Borroni, Massimiliano Marco Corsi, Massimo Locati, Alberto Mantovani. Chemokines and chemokine receptors: an overview. Frontiers in Bioscience-Landmark. 2009. 14(2); 540-551.