Open Access
Article
Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss
Parco M Siu1,Stephen E Alway1
1
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
DOI: 10.2741/3253 Volume 14 Issue 2, pp.432-452
Published: 01 January 2009
(This article belongs to the Special Issue Muscular adaptation to cellular stress)
Abstract

Apoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. The comprehensive investigation of apoptosis has been emerged in the field of skeletal muscle biology. Results have been consistent in demonstrating the activation of apoptotic machinery in different pathologic and physiologic muscle atrophic conditions including muscle disuse, hindlimb unloading, muscle dystrophy, sarcopenia, and neuromuscular diseases. Together with the other identified muscle atrophy-related signaling mechanisms such as NFk B, FOXOs/MuRF1/MAFbx and ubiquitin-proteasome, apoptosis has been advocated as an important candidate in regulating denervation-induced muscle loss. The purpose of this article is to review the role and signaling mechanisms of apoptosis during denervation in skeletal muscle including myofibers and satellite cells.

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Parco M Siu, Stephen E Alway. Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss. Frontiers in Bioscience-Landmark. 2009. 14(2); 432-452.