Open Access
Article
Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases
Vittorio Calabrese1,Carolin Cornelius1,Cesare Mancuso1,Eugenio Barone1,Stella Calafato1,Timothy Bates1,Enrico Rizzarelli1,Albena T Dinkova Kostova1
1
Department of Chemistry, Biochemistry and Mol. Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
DOI: 10.2741/3250 Volume 14 Issue 1, pp.376-397
Published: 01 January 2009
(This article belongs to the Special Issue Aging and neuroprotection)
Abstract

The ability of a cell to counteract stressful conditions, known as cellular stress response, requires the activation of pro-survival pathways and the production of molecules with anti-oxidant, anti-apoptotic or pro-apoptotic activities. Among the cellular pathways conferring protection against oxidative stress, a key role is played by vitagenes, which include heat shock proteins (Hsps) heme oxygenase-1 and Hsp70, as well as the thioredoxin/thioredoxin reductase system. Heat shock response contributes to establish a cytoprotective state in a wide variety of human diseases, including inflammation, cancer, aging and neurodegenerative disorders. Given the broad cytoprotective properties of the heat shock response there is now strong interest in discovering and developing pharmacological agents capable of inducing stress responses. Dietary antioxidants, such as curcumin, L-carnitine/acetyl-L-carnitine and carnosine have recently been demonstrated in vitro to be neuroprotective through the activation of hormetic pathways, including vitagenes. In the present review we discuss the importance of vitagenes in the cellular stress response and analyse, from a pharmacological point of view, the potential use of dietary antioxidants in the treatment of neurodegenerative disorders in humans.

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Vittorio Calabrese, Carolin Cornelius, Cesare Mancuso, Eugenio Barone, Stella Calafato, Timothy Bates, Enrico Rizzarelli, Albena T Dinkova Kostova. Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Frontiers in Bioscience-Landmark. 2009. 14(1); 376-397.