Open Access
Neural-immune system interactions in Xenopus
Kevin S Kinney1,Nicholas Cohen1
Department of Biology, DePauw University, Greencastle, IN 46135, USA.
DOI: 10.2741/3233 Volume 14 Issue 1, pp.112-129
Published: 01 January 2009

In Xenopus, as in mammals, there is a functionally significant bidirectional communication between the neuroendocrine and immune systems. In this review, we describe the evidence for the neural innervation of Xenopus lymphoid organs, review the effects of neurotransmitter and hormone manipulations on measures of immunity, and discuss the role of hormones on immunological changes during metamorphosis. We also speculate as to the phylogenetic significance of these data, and outline possible areas of future research.

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Kevin S Kinney, Nicholas Cohen. Neural-immune system interactions in Xenopus. Frontiers in Bioscience-Landmark. 2009. 14(1); 112-129.