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AMPK: Lessons from transgenic and knockout animals
Benoit Viollet1,Yoni Athea1,Remi Mounier1,Bruno Guigas1,Elham Zarrinpashneh1,Sandrine Horman1,Louise Lantier1,Sophie Hebrard1,Jocelyne Devin-Leclerc1,Christophe Beauloye1,Marc Foretz1,Fabrizio Andreelli1,Renee Ventura-Clapier1,Luc Bertrand1
1
Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Department Endocrinology, Metabolism and Cancer, Paris, France. viollet@cochin.inserm.fr
DOI: 10.2741/3229 Volume 14 Issue 1, pp.19-44
Published: 01 January 2009
(This article belongs to the Special Issue AMP-activated protein kinase)
Abstract

AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, has been proposed to function as a fuel gauge to monitor cellular energy status in response to nutritional environmental variations. AMPK system is a regulator of energy balance that, once activated by low energy status, switches on ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis), and switches off ATP-consuming anabolic pathways (such as lipogenesis), both by short-term effect on phosphorylation of regulatory proteins and by long-term effect on gene expression. Numerous observations obtained with pharmacological activators and agents that deplete intracellular ATP have been supportive of AMPK playing a role in the control of energy metabolism but none of these studies have provided conclusive evidence. Relatively recent developments in our understanding of precisely how AMPK complexes might operate to control energy metabolism is due in part to the development of transgenic and knockout mouse models. Although there are inevitable caveats with genetic models, some important findings have emerged. In the present review, we discuss recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway.

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Benoit Viollet, Yoni Athea, Remi Mounier, Bruno Guigas, Elham Zarrinpashneh, Sandrine Horman, Louise Lantier, Sophie Hebrard, Jocelyne Devin-Leclerc, Christophe Beauloye, Marc Foretz, Fabrizio Andreelli, Renee Ventura-Clapier, Luc Bertrand. AMPK: Lessons from transgenic and knockout animals. Frontiers in Bioscience-Landmark. 2009. 14(1); 19-44.