Open Access
Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders
J Luis Lujan1,Ashutosh Chaturvedi1,Cameron C McIntyre1
Department of Biomedical Engineering, Cleveland Clinic Foundation; Cleveland, Ohio 44195, USA
DOI: 10.2741/3124 Volume 13 Issue 15, pp.5892-5904
Published: 01 May 2008

Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.

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J Luis Lujan, Ashutosh Chaturvedi, Cameron C McIntyre. Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. Frontiers in Bioscience-Landmark. 2008. 13(15); 5892-5904.