Open Access
Article
Protein tyrosine phosphatases in the JAK/STAT pathway
Dan Xu1,Cheng-Kui Qu1
1
Department of Medicine, Division of Hematology/Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
DOI: 10.2741/3051 Volume 13 Issue 13, pp.4925-4932
Published: 01 May 2008
(This article belongs to the Special Issue JAKSTAT signaling in hematopoiesis)
Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.

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Dan Xu, Cheng-Kui Qu. Protein tyrosine phosphatases in the JAK/STAT pathway. Frontiers in Bioscience-Landmark. 2008. 13(13); 4925-4932.