Open Access
Article
Trimeric G protein-dependent signaling by Frizzled receptors in animal development
Diane Egger-Adam1, Vladimir L Katanaev1
1
Department of Biology, University Konstanz, P.O. Box 643, 78457 Konstanz, Germany
DOI: 10.2741/3036 Volume 13 Issue 12, pp.4740-4755
Published: 01 May 2008
(This article belongs to the Special Issue Heterotrimeric G proteins in development)
Abstract

Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.

Share and Cite
Diane Egger-Adam, Vladimir L Katanaev. Trimeric G protein-dependent signaling by Frizzled receptors in animal development. Frontiers in Bioscience-Landmark. 2008. 13(12); 4740-4755.