Open Access
Article
Lymphocytic choriomeningitis infection of the central nervous system
Silvia S Kang1,Dorian B McGavern1
1
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
DOI: 10.2741/3021 Volume 13 Issue 12, pp.4529-4543
Published: 01 May 2008
(This article belongs to the Special Issue Neurotropic virus infections and the host immune response)
Abstract

Viral infection of the central nervous system (CNS) can result in a multitude of responses including pathology, persistence or immune clearance. Lymphocytic choriomeningitis virus (LCMV) is a powerful model system to explore these potential outcomes of CNS infection due to the diversity of responses that can be achieved after viral inoculation. Several factors including tropism, timing, dose and variant of LCMV in combination with the development or suppression of the corresponding immune response dictates whether lethal meningitis, chronic infection or clearance of LCMV in the CNS will occur. Importantly, the functionality and positioning of the LCMV-specific CD8+ T cell response are critical in directing the subsequent outcome of CNS LCMV infection. Although a basic understanding of LCMV and immune interactions in the brain exists, the molecular machinery that shapes the balance between pathogenesis and clearance in the LCMV-infected CNS remains to be elucidated. This review covers the various outcomes of LCMV infection in the CNS and what is currently known about the impact of the virus itself versus the immune response in the development of disease or clearance.

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Silvia S Kang, Dorian B McGavern. Lymphocytic choriomeningitis infection of the central nervous system. Frontiers in Bioscience-Landmark. 2008. 13(12); 4529-4543.