Open Access
How axons see their way--axonal guidance in the visual system
Corinna Haupt1,Andrea B Huber1
Institute of Developmental Genetics, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D-85764 Munich/Neuherberg, Germany
DOI: 10.2741/2915 Volume 13 Issue 8, pp.3136-3149
Published: 01 January 2008
(This article belongs to the Special Issue Genetics of vision and cognition)

In humans up to 80% of the information received from the outside world is processed by the visual pathway. Therefore, understanding the molecular and cellular bases of the formation of the retinofugal projection has been in the focus of research during the last decades. Besides our interest in the development of the visual pathway per se this circuit is also an excellent model system to study axon guidance, midline crossing, and formation of topographic neuronal maps in general. The generation of genetic animal models as well as the design of in vitro loss- and gain-of-function paradigms have provided insight into transcriptional networks, identified signalling molecules, extracellular matrix components, morphogens, and activity patterns which are involved in the establishment of the visual pathway. To provide a picture as complete as possible, we will summarize molecular mechanisms involved in axon guidance and retinotopic mapping as well as neuronal activity shaping retinal and thalamocortical projections focusing on the mouse as a model system and highlight discoveries made in other organisms that contribute to our understanding.

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Corinna Haupt, Andrea B Huber. How axons see their way--axonal guidance in the visual system. Frontiers in Bioscience-Landmark. 2008. 13(8); 3136-3149.