Open Access
Article
Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli
Jose A Rodriguez1,Josune Orbe1,Sara Martinez de Lizarrondo1,Olivier Calvayrac1,Cristina Rodriguez1,Jose Martinez-Gonzalez1,Jose A Paramo1
1
Atherosclerosis Research Laboratory, Division of Cardiovascular Sciences. CIMA-University of Navarra. Avda. Pio XII 55, 31008 Pamplona, Spain. josean@unav.es
DOI: 10.2741/2896 Volume 13 Issue 8, pp.2916-2921
Published: 01 January 2008
Abstract

Atherosclerosis is the common pathophysiological substrate of ischemic vascular diseases and their thrombotic complications. The unbalance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) has been hypothesized to be involved in the growth, destabilization, and eventual rupture of atherosclerotic lesions. Different MMPs have been assigned relevant roles in the pathology of vascular diseases and MMP-10 (stromelysin-2) has been involved in vascular development and atherogenesis. This article examines the pathophysiological role of MMPs, particularly MMP-10, in the onset and progression of vascular diseases and their regulation by pro-inflammatory stimuli. MMP-10 over-expression has been shown to compromise vascular integrity and it has been associated with aortic aneurysms. MMP-10 is induced by C-reactive protein in endothelial cells, and it is over-expressed in atherosclerotic lesions. Additionally, higher MMP-10 serum levels are associated with inflammatory markers, increased carotid intima-media thickness and the presence of atherosclerotic plaques. We have cloned the promoter region of the MMP-10 gene and studied the effect of inflammatory stimuli on MMP-10 transcriptional regulation, providing evidences further supporting the involvement of MMP-10 in the pathophysiology of atherothrombosis.

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Jose A Rodriguez, Josune Orbe, Sara Martinez de Lizarrondo, Olivier Calvayrac, Cristina Rodriguez, Jose Martinez-Gonzalez, Jose A Paramo. Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli. Frontiers in Bioscience-Landmark. 2008. 13(8); 2916-2921.