Open Access
Article
Cell cycle control as a basis for cancer chemoprevention through dietary agents
Syed Musthapa Meeran1,Santosh Kumar Katiyar1
1
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
DOI: 10.2741/2834 Volume 13 Issue 6, pp.2191-2202
Published: 01 January 2008
(This article belongs to the Special Issue Cancer chemoprevention - 2)
Abstract

The development of cancer is associated with disorders in the regulation of the cell cycle. The purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure DNA stability in the face of genotoxic stress. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (CDK) molecules. The cyclins are CDK binding partners which are required for kinase activity and their protein levels are intimately linked to the cell cycle stage. CDK activity can be regulated by other mechanisms, such as phosphorylation events, that may contribute to deregulation of cell cycle and the development of cancer. While fruits and vegetables are recommended for prevention of cancer, their active ingredients and mechanisms of action are less well understood. Here, we briefly present evidence that dietary agents identified from fruits and vegetables can act to modulate the effects of deregulated cell cycle checkpoints, and that this may contribute to the prevention of cancer. The agents include apigenin (celery, parsley), curcumin (turmeric), (-)-epigallocatechin-3-gallate (green tea), resveratrol (red grape, peanuts and berries), genistein (soybean), and silymarin (milk thistle). The teachings of Hippocrates are still true "let food be thy medicine and medicine be thy food".

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Syed Musthapa Meeran, Santosh Kumar Katiyar. Cell cycle control as a basis for cancer chemoprevention through dietary agents. Frontiers in Bioscience-Landmark. 2008. 13(6); 2191-2202.